December 10th, 2011

Research plan:

The bioorganic chemistry research group at the Institute of Chemistry is dedicated to the studies on the mechanisms of the functioning of heptahelix receptors and their regulatory proteins, the key players in chemical signal transduction in nervous system. During the last years, classical molecular pharmacological methods with radioligands were implicated to study molecular recognition mechanisms as well as their connection with different physiological behaviors. At the same time we have started to implement new fluorescence based methods together with new virus-based targets. In parallel, we have worked out new synthetic strategies of substituted hydrazines which are valuable precursors for generation of new drugs and materials. Fluorescence applications created several new dimensions of molecular recognition studies, allowing monitoring of reactions in time (new parameters & models with G4 and G6) and in combination with surface plasmonic methods. This, in collaboration with G1 (theory) and G2 (optics), increases determination sensitivities, giving a new approach for understanding molecular recognition processes, and so is base for generation of new biosensors for determination of different substances.

G5 group:

  1. Ago Rinken, PhD
  2. Sergei Kopantšuk, PhD
  3. Uno Mäeorg, PhD
  4. Olga Tšubrik, PhD
  5. Ain Uustare, PhD
  6. Argo Vonk, PhD
  7. Laura Herm, PhD
  8. Santa Veikšina, PhD


  1. Oliver Pulges, doctoral student
  2. Reet Reinart, doctoral student
  3. Lauri Tõntson, doctoral student
  4. Indrek Viil, doctoral student